The Code Breaker

All of my friends raved about this book and we talked about it for over a month. I knew I had to read it. The Code Breaker is a biography of sorts. Scientist Jennifer Doudna's professional life is featured as well as the rush among the scientific field to develop the CRISPR technology.  CRISPR is the acronym for Clustered Relatively Interspersed Short Palindrome Repeats.  It can be used as a gene editing tool to cure diseases. When COVID-19 broke out, researchers had a head up on developing the COVID-19 vaccine because of the CRISPR technology.

The book opens with several chapters on Doudna's childhood. Her experiences as a white person in Hawaii formed her tenacious personality. She was regularly harassed by the Polynesian kids in her Hilo community because of her race. She was the rare Caucasian in Hilo. However, it taught her to focus on what was important, a trait that helped her in her work life.  

Several other scientists worked with Doudna on and off. Emmanuelle Charpentier is the first one I will mention as she and Doydna won the Nobel Prize for chemistry together in 2020. This award was given despite an ongoing court case over the CRISPR patents in the U. S. Supreme Court. Another scientist, Feng Zhang, fast tracked his patent application so that he would be the first person to obtain the CRISPR patent. His application was filed 3 weeks after Doudna filed hers.  His application contained false statements over who did what work. Zhang narrowed his patent application to push out other scientists who he worked with at the Broad Institute, George Church.and Luciano Marraffini. Normally 3 people are together awarded the Nobel Prize. Zhang would have been the 3rd person but that would have left out Marraffini who did most of the Zhang's work at the Broad Institute. 

Most of the scientists who did research on DNA and RNA as well as the developing CRISPR technology were doing it out of a passion for science, not financial gain. Zhang is the exception here. The other scientists were Blake Wiedenheft, Francisco Mojica, James Watson, Krzysztof Chilinski, Rodolphe Barrangou, and Le Cong. There are chapters in the book on their work as well. All worked on and off with Doudna. 

Code Breaker is a fascinating look at the search for new biotechnologies in the 21st century. 5 out of 5 stars.